It happened at 3 p.m. on the 4200 block of Hillside Rd.
According to APD, a vehicle driven by a 56-year-old man was driving east in the westbound lane of Hillside, when he hit a vehicle driven by a 37-year-old woman, and then hit another vehicle driven by an 18-year-old woman.
All three drivers were taken to the hospital with possible life-threatening injuries.
Police said alcohol is a factor in the crash and charges are pending.
The crash is still under investigation.
Editor’s note: This story was updated with additional information from the Amarillo Police Department.